Feed & Media Development

By: Sigma Aldrich  05/12/2011
Keywords: raw materials

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SAFC® has extensive experience manufacturing customized media, buffers, concentrates, feeds and supplements to match your needs. We routinely provide customers with vitamin, trace element, amino acid and hydrolysate feeds, as well as customized formulations of our existing catalog or customer-owned products.  A comprehensive process is applied to our approach to client projects. We listen to your needs and requirements and design our development approaches to meet your specifications. We design our formulations to be scaleable from bench to bioreactor, and know that your needs may differ or change at various stages of development.  Here is a  demonstrating our expertise, experience and customer support, as well as a about Designing Feed Strategies for Fed-Batch CHO Cultures. A examines Development and Application of a Chemically Defined Bioreactor Feed for CHO Cells.  We design and quantitatively monitor our projects to meet your specific cell culture requirements. Many components and operational variables are manipulated and monitored during media/feed development to assure optimal performance: 
  • Product expression and recovery - quantity and quality (recombinant protein, monoclonal antibody, virus, etc.)
  • Cell growth rate, doubling times
  • Culture longevity (IVC - Integrated Viable Cell Density)
  • ADCC - Antibody-Dependent Cellular Cytotoxicity
  • Cell attachment, clumping, etc.
  • Cryopreservation and recovery
  • Seed density
  • pH and temperature ranges
We also understand the need for regulatory compliance and design with compendial grade raw materials (USP, EP, JP) in mind. We routinely design:
  • Animal-component free media/feeds
  • Protein-free media/feeds
  • Chemically defined media/feeds

 

Keywords: raw materials

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