By: Cellix  05/12/2011

  • Applicable for cell rolling and adhesion studies to adhesion molecules or cell-cell interaction studies.

  • Suitable for a wide range of cell suspensions (primary and cell lines) including T-cells, monocytes, pbmcs, neutrophils, eosinophils, platelets and whole blood (heparanized).

  • Vena8 Fluoro+TM and Vena8TM:   Easy to coat microcapillaries with standard pipette with a range of different adhesion molecules including VCAM, ICAM, MAdCAM, fibronectin, vWF, collagen, fibrinogen etc.

  • Vena8 Endothelial+TM and VenaECTM:  Easy to seed and culture a variety of endothelial cells (monolayers) including HUVEC, HMVEC, HCAECs etc.

  • Biochip plastic is optically clear permitting detailed microscopy studies.

  • 0.05 to 20 dyne/cm2 shear stresses easily obtained and controlled by the Mirus TM Nanopump.

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    Our solutions can be used to measure cell rolling, adhesion, migration and transmigration to antibody-coated or endothelial cell-cultured microcapillaries, producing IC50 curves under shear stress conditions mimicking microcapillary, venous or arterial physiological flow.


    Vena8 Fluoro

    As cells flow through the microcapillary of the Vena8 Fluoro+™ biochip, the cell surface receptors may interact with adhesion molecules or ligands which coat the microcapillary walls. The Vena8 Fluoro+™ biochip is ideal for studying cell receptor-ligand interaction and is compatible with confocal microscopy.


    Vena8 Endothelial

    As cells flow through the microcapillary of the Vena8 Endothelial+™ biochip, the cell surface receptors may interact with the endothelial cell monolayer which coats the microcapillary walls. Adhesion of THP-1 monocytes at shear stress of 0.5 dyne/cm2 to primary HUVEC cultured in microcapillary. Endothelial cells are easily seeded and cultured inside the microcapillaries of the biochip.